Acetazolamide Does Not Disrupt Limb Regenerate Morphogenesis in the Salamander, Plethodon cinereus
Dinsmore CE and Maren TH. 1986. Acetazolamide Does Not Disrupt Limb Regenerate Morphogenesis in the Salamander, Plethodon cinereus. Teratology. 33(1):85-91
'Acetazolamide, a potent and highly specific inhibitor of carbonic anhydrase, is teratogenic in mammalian embryos and when administered during early limb development causes unique limb defects in a time and dose dependent manner.' 'This study demonstrates that while carbonic anhydrase inhibition is toxic to the red-backed salamander, Plethodon cinereus, it does not have the same teratogenic effect on limb regeneration as seen in mammalian limb development.' Red-backed Salamanders used in this study were collected from the Salsbury Cove area /STUDY LOCATIONS:/ /MOUNT DESERT ISLAND/Salsbury Cove/
- Type
- Journal Article
- Authors
- Dinsmore, Charles; Maren, Thomas
- Units
- ACAD
- Keywords
- Amphibians (Amphibia), Mount Desert Island, red-backed salamander (Plethodon cinereus), Salamanders (Caudata), Salsbury Cove