Proposal for Remote Ballistic Delivery of Brucella abortus Vaccine to Wildlife Vectors in Yellowstone National Park
Grainger DW. 2011. Proposal for Remote Ballistic Delivery of Brucella abortus Vaccine to Wildlife Vectors in Yellowstone National Park. YCR-2011-08. National Park Service, Yellowstone National Park, Yellowstone Center for Resources. Mammoth Hot Springs, Wyoming, USA
Executive summary: Previous work demonstrated successful proof-of-concept for a degradable ballistic brucellosis live vaccine delivered remotely to bison from a distance of 40 meters using commercial components and a novel hydrogel vaccine carrier. The Brucella vaccine system was shown to induce acceptable cellular and molecular immune responses in penned bison by remote delivery to intramuscular compartments from an air rifle. Further work is now proposed to provide some minor enhancements to the vaccine payload performance and scale the ballistic delivery system under quality controlled production scale processes for field test use in bison. This will involve negotiating supply agreements for reagents and cooperative agreements with vendors, and developing scientific and technical protocols to facilitate technology transfer to a contractor who can procure and produce the entire vaccine component line, ready-to-use biobullet vaccine formulations, and field use protocols.
- Type
- Published Report
- Authors
- Grainger, David
- Date of Issue
- 2011-06
- Publisher
- National Park Service, Yellowstone National Park, Yellowstone Center for Resources
- Units
- GRYN , YELL
- Keywords
- bison, bison bison, brucella abortus, brucellosis, greater yellowstone, remote delivery, vaccination
- Subjects
- Ecological Framework: Biological Integrity | Infestations and Disease | Animal Diseases , Ecological Framework: Biological Integrity | Focal Species or Communities | Mammals